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余景开课题组

Yu Jingkai  Ph. D.

课题组长、研究员

美国韦恩州立大学获博士学位(2006年)

Email: jkyu@ipe.ac.cn

研究领域

系统生物学:复杂疾病的分子网络行为

分子模拟:蛋白质药物化学修饰分子模拟

发表的主要论文(近5年)

[1] Ping Li, Yaling Nie, Jingkai Yu. An Effective Method to Identify   Shared Pathways and Common Factors among Neurodegenerative Diseases,   PLoS ONE, 2015, 10: e0143045.
[2] Fen Wang, Yanjie Wang, Junjie   Ji, Zhan Zhou, Jingkai Yu, Hua Zhu, Zhiguo Su, Lixin Zhang, Jianting   Zheng. Structural and Functional Analysis of the Loading Acyltransferase   from Avermectin Modular Polyketide Synthase, ACS Chemical Biology,   2015, 10: 1017-1025.
[3]Nie Yaling, Yu Jingkai*,Mining breast cancer genes with a network based noise-tolerant approach. BMC Systems Biology 2013, 7.
[4]Mu   Qimeng, Hu Tao*, Yu Jingkai*: Molecular insight into the steric   shielding effect of PEG on the conjugated staphylokinase: Biochemical   Characterization and Molecular Dynamics Simulation. Plos One 2013, 8.
[5]Xue   Xiaoying, Li Dongxia, Yu Jingkai, Ma Guanghui, Su Zhiguo, Hu Tao*:   Phenyl Linker-Induced Dense PEG Conformation Improves the Efficacy of   C-Terminally MonoPEGylated Staphylokinase. Biomacromolecules 2013, 14:   331-341.
[6]Murali, T. Pacifico, L., Yu, Jingkai, Guest S.,   Roberts, G., Finley, R., Jr., DroID 2011:  A comprehensive, integrated   resource for protein, transcription factor, RNA and gene interactions   for Drosophila, Nucleic Acids Research, 2011, 39: D736-D743. 
[7]Guest,   S., Yu, Jingkai, Liu, D., Hines, J., Kashat, M., and Finley, R., Jr, A   protein network-guided screen for cell cycle regulators in Drosophila,   BMC Systems Biology, 2011, 5: 65.
[8]Jingkai Yu, Thilakam Murali,   Russell Finley Jr.,Assigning confidence scores to protein-protein   interactions. In: Two Hybrid Technologies: Methods and Protocols.   Editors: Bernhard Suter and Erich E. Wanker, Humana Press, pp 161-174,   2012. (专著章节)
[9]聂亚玲、余景开,基于分子网络的癌症基因与非癌症基因的差异性分析,山东大学学报(理学版), 2012, 47(07), pp 6-9