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刘瑞田课题组

Liu Ruitian  Ph. D.

课题组长、研究员、团队首席

山东大学获得博士学位(1998年)

Email: rtliu@ipe.ac.cn

研究领域

治疗阿尔茨海默病、帕金森病、2型糖尿病、肿瘤等重大疾病的基因工程抗体、治疗性疫苗、多肽和重组蛋白药物研究

治疗重大疾病的天然化合物研究

淀粉样蛋白聚集规律及其聚集物生物特性的研究

发表的主要论文(近5年)

[1] Xiaolin Yu, Yanan Li, He Zhang, Yajing Su, Weiwei Zhou, Ziping   Zhang, Shaowei Wang, Pengxin Xu, Yujiong Wang, Ruitian Liu. Rutin   inhibits amylin-induced neurocytotoxicity and oxidative stress. Food    Function, 2015, 6: 3296-3306.
[2]Weiwei Zhou, Shuai Lu,   Yajing Su, Shaowei Wang, Di Xue, Xiaolin Yu, He Zhang, Peng-xin Xu,   Xixiu Xie, Ruitian Liu. Decreasing oxidative stress and   neuroinflammation with a multifunctional peptide rescues memory deficits   in mice with Alzheimer disease. Free Radical Biol. Med. 2014, 74:50-63
[3]Min   Zhao, Shaowei Wang, Yujiong Wang, Ran Zhang, Yanan Li, Yajing Su,   Weiwei Zhou, Xiao-lin Yu, Ruitian Liu. Pan-amyloid oligomer specific   scFv antibody attenuates memory deficits and brain amyloid burden in   mice with Alzheimer's disease. Curr Alzheimer Res., 2014, 11(1):69-78 
[4]He   Zhang, Yajing Su, Weiwei Zhou, Shaowei Wang, Pengxin Xu, Xiaolin Yu,   Ruitian Liu. Activated scavenger receptor a promotes glial   internalization of abeta. PLOS ONE, 2014, 9 (4): e94197
[5]Pengxin   Xu, Shaowei Wang, Xiaolin Yu, Yajing Su, Teng Wang, Weiwei Zhou, He   Zhang, Yujiong Wang, Ruitian Liu. Rutin improves spatial memory in   Alzheimer's disease transgenic mice by reducing Aβ oligomer level and   attenuating oxidative stress and neuroinflammation. Behav Brain Res.   2014, 264: 173-180
[6]Xue Di, Zhao Min, wang Yujiong, Wang Li,   Yang Yang, Wang Shao-Wei, Zhang Ran, Zhao Yang, Liu Rui-tian. A   multifunctional peptide rescues memory deficits in Alzheimers disease   transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing   microglial phagocytosis. Neurobiology of Disease, 2012, 46: 701-709. (IF   5.271)
[7]Yang Shi-gao, Wang Shao-wei, Zhao Min, Zhang Ran, Zhou   Wei-wei, Li Ya-nan, Su Ya-jing, Zhang He, Yu Xiao-lin, Liu Rui-tian. A   peptide binding to the   β-site of APP improves apatial memory and   attenuates Aburden in alzheimers disease transgenic mice. PLOS ONE,   2012, 7, e48540. (IF 4.537)
[8]Wang Shao-wei, Wang Yu-Jiong, Zhou   Wei-wei, Yang Shi-gao, Su Ya-jing, Zhang Ran, Zhao Min, Zhan Da-wei, Liu   Rui-tian. Rutin inhibits beta-amyloid aggregation and cytotoxicity,   attenuates oxidative stress, and decreases the production of nitric   oxide and proinflammatory cytokines. NeuroToxicology, 2012, 33: 482-490. (IF 3.394)

授权和申请发明专利(近5年)

[1] 刘瑞田,于晓琳,张燃,苏雅静,查君,一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用,申请号:201510831563.X
[2] 刘瑞田,于晓琳,查君,一种多肽及其应用,申请号:201510856645.X
[3]刘瑞田, 薛頔. 同时结合多种淀粉样蛋白单体的多肽及其应用. 发明专利,ZL 201010550987.6
[4]刘瑞田, 赵敏. 淀粉样蛋白寡聚体构象型抗原表位多肽及其应用. 发明专利,ZL201010552707.5
[4]刘瑞田, 赵敏. 淀粉样蛋白寡聚体构象型抗原表位多肽及其应用. 发明专利,ZL201010552707.5